HESA6024 Health and Safety: Randomized Control Trial

HESA6024 Health and Safety: Randomized Control Trial

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HESA6024 Health and Safety

Question:

Critical appraisal of the below-titled article

(Randomized Control Trial): Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis

Background

Diabetic ketoacidosis in children may cause brain injuries ranging from mild to severe. Whether intravenous fluids contribute to these injuries has been debated for decades.

Method

We conducted a 13-center, randomized, controlled trial that examined the effects of the rate of administration and the sodium chloride content of intravenous fluids on neuro logic outcomes in children with diabetic ketoacidosis. Children were randomly assigned to one of four treatment groups in a 2-by-2 factorial design (0.9% or 0.45% sodium chloride content and rapid or slow rate of administration). The primary outcome was a decline in mental status (two consecutive Glasgow Coma Scale scores of <14, on a scale ranging from 3 to 15, with lower scores indicating worse mental status) during treatment for diabetic ketoacidosis. Secondary outcomes included clinically apparent brain injury during treatment for diabetic ketoacidosis, short-term memory during treatment for diabetic keto acidosis, and memory and IQ 2 to 6 months after recovery from diabetic ketoacidosis.

HESA6024 Health and Safety

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